IMTAXEN
SUMATRIPTAN AND NAPROXEN · by SHAIGAN
Composition
Tab 85/500mg: Sumatriptan (as succinate) 85 mg and Naproxen sodium 500 mg
Indications & Dosage
Treatment of acute migraine, acute cluster headache: Adult: 1 tab onset of acute attack, followed by 1 tab after at least 2 hours if required, to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); max. 2 tab per day.
Contraindications
Coronary vasospasm, ischaemic heart disease, uncontrolled, moderate and severe hypertension, peripheral vascular disease, previous cerebrovascular accident, previous myocardial infarction, previous transient ischaemic attack, Prinzmetals angina, active GI bleeding or ulceration or haemorrhage (two or more distinct episodes), severe heart failure, NSIAD induced allergy, hepatic and renal failure
Precautions
Predisposition to coronary artery disease, asthma, elderly, history of seizures, mild controlled hypertension, pre-existing cardiac disease, risk factors for seizures, renal or hepatic impairment (reduce dose), allergic disorders
Interactions
MAOIs, ergotamine, SSR1s, St. Johns Wort, anticoagulants, antiplatelets, hydantoins, sulfo-nylureas, quinolones, sulphonamides, diuretics, lithium, beta-blockers, probenecid, methotrexate, cyclosporin, corticosteroids, SSRIs, cardiac glycosides, mifepristone, tacrolimus, zidovudine, other NSAIDs.
Pregnancy
Avoid unless the potential benefit outweighs the risk.
Lactation
Withhold breast-feeding for 12 hours after treatment.
Side Effects
Anxiety, arthralgia, bradycardia, diarrhoea, dizziness, drowsiness, raised blood pressure, dyspnea, fatigue, flushing, myalgia, nausea, sensory disturbances, transient increase in blood pressure, vomiting, weakness, hypersensitivity reactions, hypotension, ischaemic colitis, neck stiffness. Rare: Arrhythmias, angina, dystonia, myocardial infarction, nystagmus, palpitation, Raynauds syndrome, seizures, sweating, tachycardia, transient ischaemic ECG changes, tremor, visual disturbances