Composition
Cap/Tab 50 mg/100 mg: Minocycline 50 mg/100 mg.
Indications & Dosage
Lower respiratory infection, Upper respiratory infection, Skin infection, Urinary tract infection: Adults: 200 mg, then 100 mg every 12 hr or 50 mg every 6 hr. Children 8 yrs: 4 mg/kg, then 2 mg/kg every 12 hr.
Contraindications
Renal failure, children under 12 years (deposition in growing bone and teeth, by binding to calcium, causes staining and occasionally dental hypoplasia)
Precautions
Hepatic impairment. Monitor for hepatitis, SLE or unusual pigmentation regularly, myasthenia gravis (muscle weakness may be increased), systemic lupus erythematosus (may be exacerbated), avoid exposure to sunlight or UV light, risk of super-infection.
Interactions
Antacids, penicillins, mineral supplements.
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated, avoid
Side Effects
Dizziness, vertigo, GI disturbance, Anaphylaxis, angioedema, blood disorders, exfoliative dermatitis, hepatotoxicity, hypersensitivity reactions, pancreatitis, pericarditis, photosensitivity, rash, Stevens-Johnson Syndrome, urticaria, colitis, benign intracranial hypertension, bulging fontanelles, diarrhoea, dysphagia, headache, nausea, oesophageal irritation, visual disturbances, vomiting, anorexia, anxiety, flushing, fungal super-infection (when used for periodontitis), tinnitus, oesophageal ulcers, photosensitivity, hepatic dysfunction. Rare: pericarditis, myocarditis vasculitis, renal failure, interstitial nephritis, pancreatitis