Composition
Tab 25 mg/75 mg: Indomethacin 25 mg/75 mg. Cap 25 mg/50 mg/75 mg: Indomethacin 25 mg/50 mg/75 mg. Suppository 50 mg/100 mg: Indomethacin 50 mg/100 mg
Indications & Dosage
Pain and moderate to severe inflammation in rheumatic disease, osteoarthritis, and other musculoskeletal disorders, serious musculoskeletal injuries: ORAL: Adult & Children: 50-200 mg daily in divided doses. BY RECTUM: Adult: 100 mgSuppository twice daily if required, dose to be administered at night and in the morning, combinedoral and rectal treatment, max. total daily dose 150-200mg. Acute gout: ORAL: Adult & Children: 150-200 mg daily in divided doses. BY RECTUM: Adult: 100 mg Suppository twice daily if required, dose to be administered at night and in the morning, combinedoral and rectal treatment, max. total daily dose 150-200mg. Dysmenorrhoea: ORAL: Adult & Children: Up to 75 mg daily BY RECTUM: Adult: 100 mg Suppository twice daily if required, dose to be administered at night and in the morning, combinedoral and rectal treatment, max. total daily dose150-200mg.
Contraindications
Active GI bleeding and ulceration, history of GIbleeding or perforation related to previous NSAID therapy, history of recurrent GI haemorrhage or ulceration (two or more distinct episodes), severe heart failure, history of GIT lesions, aspirin or anti-inflammatory drug-induced allergy.
Precautions
Renal or hepatic impairment, allergic disorders, avoid rectal administration in haemorrhoids and proctitis, cardiac impairment, cerebrovascular disease, coagulation defects, connective-tissue disorders, Crohns disease (may be exacerbated),elderly, epilepsy, heart failure, ischaemic heart disease, parkinsonism, peripheral arterial disease, psychiatric disturbances, risk factors for cardiovascular events, ulcerative colitis (may be exacerbated), uncontrolled hypertension, CNS disorders.
Interactions
Salicylates, anticoagulants, lithium, corticosteroids, diuretics, beta-blockers, probenecid, quinolones.
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated
Side Effects
Angioedema, blood disorders, bronchospasm, colitis, Crohns disease, depression, diarrhoea, dizziness, drowsiness, fluid retention, GI bleeding and ulceration, GI disturbances, haematuria, headache, hearing disturbances, hypersensitivity reactions, insomnia, nausea, nervousness, photosensitivity, raised blood pressure, rashes, renal failure (especially in patients with preexisting renal impairment),tinnitus, vertigo. Rare: Hepatic damage, interstitial fibrosis associated with NSAIDs, Stevens-Johnson syndrome, toxic epidermal necrolysis, visual disturbances, exacerbation of symptoms in asthma, thrombocytopenia, aseptic meningitis