Composition
Cap 500 mg: Lincomycin (as HCI) 500 mg. Inj 150 mg (1 ml)/300 mg(1 ml)/600 mg(2 ml): Lincomycin (as HCI) 150 mg (1 ml)/300 mg(1 ml)/600 mg(2 ml) amp/Vial. Susp/Syp:Per 5 ml: Lincomycin (as H
Indications & Dosage
Infections caused by gram-positive pathogens, anaerobic infections, chronic middle ear infection, colitis, impetigo, osteomyelitis, pneumonia: ORAL: Adults: 500 mg three or four times daily; Children1-6 months: 1.25-2.5 ml three times daily; 6 months-2 yrs: 2.5-5 ml three times daily; 3-9 yrs: 2.5-5 ml four times daily; 10-12 yrs, 5-10 ml four times daily. BY IM INJ OR IV INF: Adults: 600 mg by IM inj 12-24 hourly or IV INF 8-12 hourly. Children 1 month & older: 10 mg/kg by IM inj 12-24 hourly; alternatively 10-20 mg/kg daily by IV INF in 2 or 3 divided doses at 8-12 hr intervals.
Administration
For IV injection 1 gm lincomycin diluted in not less than 100 ml of appropriate solution and infused over a period of not less than one hour. Dilute 600 mg dose in at least 100 ml D5W, 010W, NS, dextrose 5% in NS, or other compatible diluent. Dilute higher doses in 100 ml of a compatible diluent for each gm being given.
Compatibility
D5W 010W, D5NS, D1ONS. Ringers sol. In-compatible with novobiocin and kanamycin
Stability
Store at 20C-25C (68F-77F). Diluted lincomycin in an appropriate solution is physically compatible for 24 hours at room temperature unless otherwise indicated.
Contraindications
Lincosamide sensitivity.
Precautions
Renal, hepatic, endocrine or metabolic disorders. Check liver function and blood regularly with pro-longed use.
Interactions
Neuromuscular blocking drugs.
Pregnancy
Caution advised, avoid
Lactation
Contraindicated, avoid
Side Effects
Abdominal discomfort, anaphylactoid reactions, antibiotic-associated colitis, diarrhoea (discontinue treatment), eosinophilia, exfoliative dermatitis, jaundice, leucopenia, nausea, oesophageal ulcers, oesophagitis, polyarthritis, pruritus, rash, Stevens-Johnson syndrome, taste disturbances, thrombocytopenia, toxic epidermal necrolysis, urticaria, vesiculobullous dermatitis, vomiting