MASDIPINE SR
NIFEDIPINE · by MASS PHARMA
Composition
Cap 5 mg/10 mg/20 mg: Nifedipine 5 mg/10 mg/20 mg. Retard Tab 20 mg: Nifedipine 20 mg; sustained release. Tab10 mg/30 mg/60 mg: Nifedipine 10 mg/30 mg/ 60 mg. Tab30 mg/60 mg: Nifedipine 30 mg
Indications & Dosage
Raynauds syndrome: Adult: Initially 5 mg 3 times a day, then adjusted according to response to 20 mg 3 times a day. Hiccup in palliative care: Adult: 10 mg 3 times a day. Hypertension, Angina prophylaxis: Adult: 10 mg Retard Tab twice daily, adjusted according to response to 40 mg twice daily. Children: Not recommended.
Contraindications
Cardiogenic shock, unstable angina, severe aortic stenosis, within a month of Mt. Hepatic impairment, history of GI obstruction, Crohns disease, Kock pouch.
Precautions
Poor cardiac reserve, heart failure, hepatic im-pairment, severe hypotension, diabetes, dialysis, elderly.
Interactions
Anti hypertensives, cimetidine, quinidine, digoxin, rifampicin, phenytoin, diltiazem, cisapride, erythromycin, azole antifungals, fluoxetIne, indinavir, ritonavir, tacrolimus, quinupristin/dalfopristin, nefazodone, grapefruit juice.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Headache, flushes, oedema, dizziness, tachycardia, hypotension, GI upset, lethargy, paraesthesia, skin reactions, myalgia, tremor, visual disturbances, in-creased urinary frequency, gingival hyperplasia, gynaecomastia. Rare: Hypersensitivity, jaundice, impotence, mood changes. MI, ischaemic pain (discontinue).