Composition
Tab 200 mg/400 mg: Lomefloxacin(as HCI) 200 mg/400 mg.
Indications & Dosage
Respiratory-tract infections, Acute bacterial exacerbation of chronic bronchitis: Adults: 400 mg once daily for 10 days. Complicated Urinary Tract Infection: Adults: 400 mg once daily for 14 days. Uncomplicated Cystitis: Adult: 400 mg once daily for 3 days (E. coli) or 10 days (K. pneumoniae, P mirabilis, or S. saprophyticus). Children: Not recommended.
Contraindications
Hypersensitivity to quinolones.
Precautions
Avoid excessive alkalinity of urine and ensure adequate fluid intake (risk of crystalluria). Risk factor for QTinterval prolongation; caution advised in conditions such as: Acute myocardial infarction, bradycardia, congenital long QT syndrome, electrolyte disturbances, heart failure with reduced left ventricular ejection fraction, history of symptomatic arrhythmias. Risk of arthropathy in children and adolescents; evaluate risk/benefit ratio before treatment initiation, history of tendon disorder, epilepsy, history to CNS disorder, renal impairment, myasthenia gravis and elderly. Avoid prolonged exposure to UV. Discontinue treatment if psychiatric, neurological, or hypersensitivity reactions (including severe rash) occur.
Interactions
Antineoplastic agents, oral anticoagulants, NSAIDs, CYP1A2 substrates, loop diuretics, probenecid, metoclopramide, corticosteroids, methotrexate, magnesium, aluminium, calcium or iron salts, theophylline and other xanthine derivatives.
Pregnancy
Risk cannot be ruled out.
Lactation
Contraindicated or not recommended.
Side Effects
Diarrhoea, dizziness, headache, nausea, vomiting, abdominal pain, anorexia, anxiety, arthralgia, asthenia, blood disorders, confusion, depression, disturbances in taste, hearing, smell and vision, dyspepsia, eosinophilia, hallucinations, leucopenia, myalgia, rash, sleep disturbances, thrombocytopenia, tremor. Rare: antibiotic-associated colitis, convulsions, dyspnea, hepatic dysfunction, hepatitis, hypotension, interstitial nephritis, jaundice, photosensitivity, psychoses, renalfailure