Composition
Tab 50 mg: Mercaptopurine 50 mg.
Indications & Dosage
Acute lymphoblastic leukaemias, Chronic myeloid leukaemia: Adult: Initially 2.5 mg/kg daily, adjusted according toresponse, alternatively initially 50-75 mg/m2 daily, adjusted according to response.
Contraindications
Severe liver disease, severe bone marrow suppression, absent thiopurine methyltransferase activity; consider pre-treatment screening
Precautions
Renal or hepatic impairment. Monitor liver function and bloods, reduced thiopurine methyltransferase activity
Interactions
Allopurinol, warfarin, olsalazine, mesalazine, sulphasalazine.
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated. Discontinue breast-feeding
Side Effects
Alopecia, anorexia, bone-marrow suppression, hepatotoxicity, hyperuricaemia, myelosuppression, liver toxicitynausea, oral mucositis, thromboembolism, tumourlysis syndrome, vomiting Rare: Pancreatitis, transient oligospermia, Intestinal ulceration, lymphoma