MIGRIL
ERGOTAMINE, CYCLIZINE AND CAFFEINE · by GSK
Composition
Tab: Ergotamine tartrate 2 mg, cyclizine HCI 50 mg, caffeine equiv to 100 mg caffeine hydrate.
Indications & Dosage
Treatment of acute migraine and migraine variants unresponsive to analgesics: Adult: 1 tablet, to be taken at onset, followed by 0.5-1 tablet after 30 minutes, then 0.5-1 tablet every 30 minutes if required, max. 3 tablets in 24 hours, max.4 tablets per attack, max. 6 tablets in one week.
Contraindications
Acute porphyrias, coronary heart disease, hyperthyroidism, severe or uncontrolled hypertension, obliterative vascular disease, peripheral vascular disease, Raynauds syndrome, sepsis, temporal arteritis, severe renal or hepatic impairment
Precautions
Anaemia, cardiac disease, dependence, elderly, epilepsy, glaucoma, prostatic hypertrophy, pyloroduodenal obstruction, severe heart failure; may cause fall in cardiac output and associated increase in heart rate, susceptibility to angle-closure glaucoma, urinary retention.
Interactions
Erythromycin, beta-blockers, CNS depressants.
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Abdominal pain, drowsiness, dry mouth, dizziness, nausea, vomiting, cyanosis, diarrhoea, hypoaesthesia, pain and weakness in extremities, paraesthesia, peripheral vasoconstriction. Rare: Arrhythmias, bradycardia, dyspnea, ergotism, increased blood pressure, intestinal ischaemia, myalgia, rash, tachycardia, urticaria