Composition
Tab: Lynestrenol 0.5 mg.
Indications & Dosage
Disturbance of menstrual cycle: Adult (female):1 tab daily on days 14 to 25 of the cycle. The first day of the cycle is the first day of menstruation. Children: Not recommended.
Contraindications
Severe arterial disease, undiagnosed vaginal bleeding and acute porphyria, history during pregnancy of idiopathic jaundice, severe pruritus, or pemphigoid gestations, incomplete miscarriage, missed miscarriage. Avoid in hepatic impairment. Avoid in active liver disease including disorders of hepaticexcretion (e.g. Dublin-Johnson or Rotor Syndromes), infective hepatitis (until liver function returns to normal) and liver tumours and lactation
Precautions
Renal impairment, conditions that may worsen with fluid retention, epilepsy, hypertension, migraine, asthma, or cardiac dysfunction, susceptible to thromboembolism (particular caution with high dose, history of depression. Progestogens can decrease glucose tolerance and patients with diabetes should be monitored closely.While using as contraceptive wait 6 weeks post-partum if lactating.
Interactions
Rifamycin, anticoagulants, antidepressants, antidiabetics, anti-epileptics, antifungals, antivirals, aprepitant, barbiturates, bosentan, cyclosporin, diuretics, dopaminergics, lipid-regulating drugs, muscle relaxants.
Side Effects
Irregular, prolonged or heavy vaginal bleeding during first 2 or 3 cycles, menstrual disturbances, premenstrual-like syndrome (including bloating, fluid retention, breast tenderness), weight change, nausea, headache, dizziness, insomnia, drowsiness, depression, change in libido; also skin reactions (including urticaria, pruritus, rash, and acne), hirsutism, alopecia, jaundice and anaphylactoid reactions