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NELVIR

NELFINAVIR MESYLATE · by A. J. MIRZA

Composition

Tab: Nelfinavir mesylate 250 mg. Powd: Nelfinavir mesylate 50 mg.

Indications & Dosage

HIV infection in combination with other antiretroviral drugs: Adults: 1.25 gm twice daily or 750 mg 3 times daily. Children 3-13 yrs: initially 50-55 mg/kg twice daily (max 1.25 gm twice daily) or 25-30 mg/kg 3 times daily (max 750 mg 3 times daily).

Contraindications

Acute porphyria.

Precautions

Patients with hyperglycaemia, haemophilia, hepatic impairment, chronic hepatitis B or C.

Interactions

See literature.

Pregnancy

Avoid, use only when no safer alternative exists for a serious problem.

Lactation

Contraindicated

Side Effects

Anorexia, hepatic dysfunction, pancreatitis, blood disorders including anaemia, neutropenia, and thrombocytopenia, GI disturbances including di-arrhoea, nausea, vomiting, abdominal pain and flatulence, sleep disturbances, fatigue, headache, dizziness, paraesthesia, myalgia, myositis, rhabdomyolysis, taste disturbances, rash, pruritus, Stevens-Johnson syndrome, hypersensitivity reactions including anaphylaxis, lipodystrophy syndrome and osteonecrosis.