Composition
Tab 75 mg/75 mg: Clopidogrel (as hydrogen sulphate) 75 mg, aspirin 75 mg.Tab 75 mg/150 mg: Clopidogrel (as hydrogen sulphate) 75 mg, aspirin 150 mg. Tab 75 mg/81 mg: Clopidogrel (as hydrogen
Indications & Dosage
Prevention of atherothrombotic events in patients suffering from myocardial infarction (for less than 35 days), ischaemic stroke (from day 7 to 6 months) or established peripheral artery disease, in combination with aspirin in non-ST segment elevation acute coronary syndrome (unstable angina or non-C-Wave Myocardial Infarction): Adults: 1 tab daily. CHILDREN: Not recommended.
Contraindications
Do not initiate therapy within first few days after MI. PTCA (stenting), CABG acute ischaemic stroke of less than 7 days, hypoprothrombinaemia, severe hepatic impairment, bleeding dis-orders, active bleeding such as peptic ulcer or intracranial haemorrhage.
Precautions
Renal or hepatic impairment, moderate hepatic impairment, surgery, risk of bleeding and blood dyscrasias; perform blood counts, unusual bleeding, history of bronchospasm, dyspepsia.
Interactions
Anticoagulants, glycoprotein lib/Iiia inhibitors, thrombolytics, NSAIDs, hypoglycaemics, phenytoin, sodium valproate, uricosuric agents, methotrexate, sulphonamides, spironolactone, cor-ticosteroids, antacids.
Pregnancy
Contraindicated
Lactation
Not recommended.
Side Effects
Bleeding manifestation, GI upset, skin reactions, , nervous system, hepatic, biliary or, haematological disorders. Rare: thrombotic thrombocyt penic purpura