OSTEONIL
RALOXIFENE · by STANDPHARM
Composition
Tab: Raloxifene HCI 60 mg.
Indications & Dosage
Prevention of non-traumatic vertebral fractures in post-menopausal women at increased risk of osteoporosis: Adults: 1 tab daily
Contraindications
Hepatic or severe renal impairment, history of venous thromboembolic events, cholestasis, undiagnosed uterine orvaginal bleeding, endometrial or breast cancer, prolonged immobilisation. Avoid in acute porphyrias
Precautions
History of oestrogen-induced hypertriglyceridaemia (monitor serum triglycerides), risk factors for stroke, risk factors for venous thromboembolism (discontinue if prolonged immobilisation). Ensure adequate calcium and vit D intake
Interactions
Systemic oestrogens, cholestyramine, oral anticoagulants.
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Hot flushes, influenza-like symptoms, leg cramps, peripheral oedema, thrombophlebitis, venous thromboembolism. Rare: Arterial thromboembolism, breast discomfort, GI disturbances, headache, hypertension, migraine, rashes, thrombocytopenia