P-DOXIME
PRALIDOXIME METHYLSULPHATE · by ATCO
Composition
Inj: Per 10 ml: Pralidoxime Methylsulphate equiv to Pralidoxime 200 mg.
Indications & Dosage
Treatment of poisoning due to organophosphate pesticides or related compound, Adjunct to atropine in the treatment of poisoning due to pesticides & chemicals of the organophosphate class: Adults: 1-2 gm IM/ IV, max dose: 12 gm/24 hr + atropine 2 mg SC/IM repeated at intervals of 5-60 min. Children: 20-60 mg/kg. Treatment of overdosage by anti-cholinesterase drugs used in the treatment of myasthenia gravis: Adult & Children: 1-2 gm IV followed by increments of 250 mg every 5 min.
Precautions
Renal insufficiency, elderly, pregnancy and lactation.
Interactions
Morphine, theophylline, aminophylline, succinyl-choline, reserpine and phenothiazine type tranquillisers.
Side Effects
Headache, disturbances of vision, dizziness, drowsiness, hyperventilation, muscular Weakness, nausea, tachycardia