Composition
Int Per 125 ml: Pefloxacin 400 mg. Tab 400 mg: Pefloxacin 400 mg.
Indications & Dosage
Respiratory tract infections, ENT infections, gynaecological infections, UTI, abdominal and hepato-biliary infections, bone and joint infections, skin infections, septicaemia and endocarditis, meningitis: ORAL OR BY IV INF: Adults: 400 mg twice daily.Children: Not recommended.
Administration
Adults: 400 mg in D5W (250 ml), adminis-tered by slow IV infusion over 1 hr twice daily.
Contraindications
Glucose-6-phosphate dehydrogenase deficiency.
Precautions
Severe hepatic insufficiency, avoid exposure to the sun or ultraviolet light during treatment. Should not be prescribed as first line treatment in respiratory tract infections when a bacteriological examination has not been carried out, as Streptococciand pneumococci show only intermediate susceptibility.Risk factor for QTinterval prolongation; caution advised in conditions such as: Acute myocardial infarction, bradycardia, congenital long QT syndrome, electrolyte disturbances, heart failure with reduced left ventricular ejection fraction, history ofsymptomatic arrhythmias.
Interactions
Antacids containing aluminium or magnesium hydroxide, Theophylline.
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Diarrhoea, dizziness, headache, nausea, vomiting, abdominal pain, anorexia, anxiety, arthralgia, asthenia, blood disorders, confusion, depression, dyspepsia, eosinophilia, hallucinations, leucopenia, myalgia, rash, sleep disturbances, thrombocytopenia, tremor. Rare: antibiotic-associated colitis, convulsions, dyspnea, hepatic dysfunction, hepatitis, hypotension, interstitial nephritis, jaundice, photosensitivity, psychoses, renal failure, symptoms