Composition
Tab 5 mg/10 mg: s 5 mg/10 Mg.
Indications & Dosage
In combination with aspirin for the prevention of atherothrombotic events in patients with acute coronary syndrome undergoing percutaneous coronary intervention: Adult 18-75+ yrs (body-weight up to 60 kg): Initially60 mg for 1 dose, then 5 mg once daily up to 1 yr. Adult 18-74 yrs (body-weight 60 kg and above): Initially60 mg for 1 dose, then 10 mg once daily up to 1 yr. Patients undergoing coronary angiography within 48 hours of admission for unstable angina or NSTEMI: Adult: Loading dose 60 mg, only at the time of percutaneous coronary intervention to minimize the risk of bleeding, maintenance dose of 10 mg or 5mg daily according to age and weight of patient. Alternative to clopidogrel in certain patients undergoing percutaneous coronary intervention: Adult: 60 mg, as a single dose Children: Not recommended.
Contraindications
History of stroke or transient ischaemic attack, active bleeding.
Precautions
Patients with high risk of bleeding from recent trauma, surgery, gastro-intestinal bleeding, or active peptic ulcer disease, concomitant use of drugs that increase risk of bleeding; discontinue at least 7 days before elective surgery if antiplatelet effect not desirable, elderly..
Interactions
NSAIDs, cournarins, phenindione, clopidogrel.
Pregnancy
Risk cannot be ruled out
Lactation
Caution advised or effect undetermined.
Side Effects
Gestro-intestinal, Intracranial and other haemorrhage, haematoma, haematuria, anaemia, rash, angioedema, hypersensitivity reactions. Rare: Thrombocytopenia