PG MIN
PIOGLITAZONE AND METFORMIN · by NOVINS
Composition
Tab 15/500 mg: Pioglitazone 15 mg, metformin500 mg. Tab 15/850 mg: Pioglitazone 15 mg, metformin 850 mg.
Indications & Dosage
Type 2 diabetes not controlled by metformin alone, particularly in obese: Adult: 1 tablet twice daily, titration with the individual components (pioglitazone and metformin) desirable before initiation Children: Not recommended.
Contraindications
History of heart failure, previous or active bladder cancer, severe infection, shock, trauma, uninvestigated haematuria, dialysis, diabetic ketoacidosis, pregnancy and lactation.
Precautions
Porphyrias, monitor for fluid retention or other signs of cardiac failure (discontinue if deteriorates). Monitor for risk factors for lactic acidosis. Monitor for weight gain and anaemia. Withdraw 48 hours before elective surgery. Monitor for signs of hepatic dysfunction and check liver enzymes prior to therapy and every 2 months thereafter, elderly, risk of bone fracture and bladder cancer particularly in women and elderly.
Interactions
Insulin (contraindicated), NSAIDs, gemfibrozil, rifampicin. Insulin, gemfibrozil, rifampicin, NSAIDs, intravascular iodinated contrast media, alcohol, cimetidine, cocorticosteroids, beta2-agonists, diuretics, ACE inhibitors,
Pregnancy
Contraindicated or not recommended
Lactation
Contraindicated or not recommended.
Side Effects
GI disturbances, anaemia, arthralgia, dizziness, haematuria, headache, hypoaesthesia, impotence, oedema, vertigo, visual disturbances, weight gain, altered blood lipids, bladder cancer, fatigue, hypoglycaemia, insomnia, proteinuria, sweating, rare; liver dysfunction.