PHEE-PHRINE
PHENYLEPHRINE · by BAJWA
Composition
Inj: Per ml: Phenylephrine 10 mg.
Indications & Dosage
Acute hypotension: BY SC INJ, OR BY IM INJ: Adult: Initially 2-5 mg, followed by 1-10 mg, after at least 15 minutes if required BY SLOW IV INJ: Adult: 100-500 mcg, repeated as necessary after at least 15 minutes BY IV INF: Adult: Initially up to 180 mcg/min, reduced to 30-60 mcg/min, adjusted according to response Paroxysmal supraventricular tachycardia: BY IV INF: Adults: 250-500 mcg per dose over 20 to 30 sec.Children: 5-10 mcg per dose over 20 to 30 sec.
Administration
10 mg in 500 ml (concentration: 20 mcg/ml).
Compatibility
Stable in dextran 6% in dextrose, dextran 6% in NS, D5LR, 05 1/4NS, 05 1/2NS, D5NS, D1OW, D5W, NS, LR, 1/2 NS, sodium bicarbonate 5%.
Contraindications
Severe hypertension, ventricular tachycardia, severe hyperthyroidism
Precautions
Coronary disease, coronary or peripheral or mesenteric vascular thrombosis, diabetes, elderly, following myocardial infarction, hypercapnia, hyperthyroidism, hypoxia, Prinzmetals variant angina, uncorrected hypovolaemia
Interactions
Ergot derivatives, hyaluronidase, lobenguane, MAOls, TCAs.
Pregnancy
Caution advised, avoid
Lactation
Caution advised
Side Effects
Angle-closure glaucoma, anorexia, anxiety, arrhythmias, bradycardia, confusion, dyspnea, headache, hypertension, hypoxia, insomnia, nausea, palpitation, peripheral ischaemia, psychosis, tachycardia, tremor, urinary retention, vomiting, weakness, extravasation at injection site may cause necrosis