Composition
Tab 200 mg: Pirfenidone 200 mg Tab 267 mg: Pirfenidone 267 mg Tab 801 mg: Pirfenidone 801 mg
Indications & Dosage
Treatment of mild to moderate Idiopathic Pulmonary Fibrosis: Adult: Initially 267 mg 3 times a day for 7 days, then increased to 534 mg 3 times a day for 7 days, then increased to 801 mg 3 times a day.
Contraindications
Cigarette smoking, severe renal or hepatic impairment
Precautions
Photosensitivity Avoid exposure to direct sunlight, if rash occurs, dose adjustment or treatment interruption may be required. If treatment is interrupted for 14 consecutive days or more, the initial 2 week titration regimen should be repeated; if treatment is interrupted for less than 14 consecutive days, the dose can be resumed at the previous daily dose without titration. Monitor for weight loss. Test liver function before treatment, then at monthly for the next 6 months, and then every 3 months thereafter; if abnormal liver function tests; dose reduction, treatment interruption or discontinuation may be required (consult product literature).
Interactions
Ciprofloxacin, ofloxacin, antidepressants, rifampin, fluoxetine, duloxetine, carbamazepine
Pregnancy
Avoid unless essential
Lactation
Avoid
Side Effects
Headache, decreased appetite, dizziness, drowsiness, arthralgia, asthenia, diarrhea, constipation, cough, dyspnea, GI disorders, hot flush, insomnia, musculoskeletal chest pain, myalgia, nausea, vomiting, photosensitivity reaction, skin reactions, taste altered, weight loss. Rare: Angioedema, agranulocytosis