Composition
Tab5 mg: Procyclidine HCI 5 mg. Inj 10 mg: Per 2 ml: Procyclidine 10 mg. Syp 2.5 mg/5 mg: Per 5 ml: Procyclidine 2.5 mg/5 mg.
Indications & Dosage
Parkinsonism, Extra pyramidal symptoms (but not tardivedyskinesia): Adult: 2.5 mg 3 times a day, then increased in steps of2.5-5 mg daily if required; increased if necessary up to 30 mg daily in 2-4 divided doses, at2-3 day intervals. max. daily dose only to be used in exceptional circumstances; max. 60 mg per day. Elderly: Lower end of range preferable. Acute dystonia: BY IM INJ, OR BY IV INJ: Adult: 5-10 mg, occasionally, more than 10 mg, dose usually effective in 5-10 minutes but may need 30 minutes for relief. Elderly: Lower end of range preferable.
Contraindications
GI obstruction, myasthenia gravis,urinary obstruction, closed angle glaucoma.
Precautions
Cardiovascular disease, elderly, hypertension, liable to abuse, prostatic hypertrophy, psychotic disorders, pyrexia, susceptible to angle-closure glaucoma, narrow angle glaucoma.Withdraw slowly.
Interactions
Phenothiazines, antihistamines and antidepressants.
Pregnancy
Use only if potential benefit outweighs risk.
Lactation
Contraindicated
Side Effects
Anxiety, angle-closure glaucoma, blurredvision,confusion,constipation,dizziness,dry mouth, euphoria,gingivitis,hallucinations,impaired memory, nausea,rash, restlessness, tachycardia, urinary retention, vomiting