RADIM INSTA
OMEPRAZOLE AND SODIUM BICARBONATE · by NEUTRO PHARMA
Composition
Cap 20 mg/1100 mg: Omeprazole 20 mg and sodium bicarbonate 1100 mg. Cap 40 mg/1100 mg: Omeprazole 40 mg and sodium Bicarbonate 1100 mg. Powd 20 mg/1100 mg: Omeprazole 20 mg and sodium bicarb
Indications & Dosage
Reflux oesophagitis: Adults: 20 mg once daily for 4 wk, extend for a further 4-8 weeks if not fully healed. Refractory cases: Adults: 40 mg once daily. Acid-reflux disease: Adults: Long-term management, 10 mg once daily, increased to 20 mg once daily if symptoms return. Benign Duodenal ulceration: Adults: 20 mg once daily for 4 weeks. Severe cases; increased to 40 mg once daily. Prevention of relapse: Adults:10 mg once daily, increasing to 20 mg once daily if symptoms return. Duodenal ulceration with Helicobacter pylori: Adults: 40 mg daily with amoxicillin 1.5-2 gm daily for 2 weeks. Benign Gastric ulceration: Adults: 20 mg once daily for 8 wk. Severe cases: increase to 40 mg once daily. Zollinger-Ellison syndrome: Adults: 60 mg once daily adjusted to response. Usual maintenance: 20-120 mg daily. Doses over 80 mg daily are given in two divided doses Acid aspiration: Adults: 40 mg in the evening of day before surgery, then 40 mg 1-4 hour prior to surgery. Children: Not recommended.
Precautions
Exclude malignancy before treatment, hepatic impairment. Monitor serum B12 in severely ill patients on long term treatment.
Interactions
Phenytoin, warfarin, digoxin Diazepam, ketoconazole, itraconazole.
Pregnancy
Risk cannot be ruled out.
Lactation
Not recommended.
Side Effects
Headache, somnolence, insomnia, arthralgia, GI upset, skin rashes, paraesthesia, dizziness, myalgia, increased risk of GI infections. Increase in liver enzymes.