Composition
Tab 150 mg/300 mg: Aliskiren 150 mg/300 mg.
Indications & Dosage
Essential hypertension either alone or in combination with other anti-hypertensives: Adult: 150 mg once daily, increased if necessary to 300 mg once daily.
Contraindications
Concomitant treatment with an ACE inhibitor or an angiotensin-II receptor antagonist in patients with an eGFR less than 60 ml/minute/1.73m2, concomitant treatment with an ACE inhibitor or an angiotensin-II receptor antagonist in patients with diabetes mellitus, hereditary angioedema, idiopathic angioedema Children: Not recommended.
Precautions
First dose may cause hypotension in patients taking concomitant diuretics, on a low sodium diet, or who are dehydrate - initiate with care, renal artery stenosis, renal impairment, monitor plasma-potassium concentration and renal function in renal impairment, diabetes mellitus and heart failure.Monitor plasma-potassium concentration in renal impairment. Monitor patients with a history of angioedema closely during treatment
Interactions
Angiotensin-II receptor antagonists, anticoagulants, antifungals, diuretics, potassium salts.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Arthralgia, dizziness, hyperkalaemia, diarrhoea, liver disorders, nausea, vertigo, vomiting. Rare: Acute renal failure (reversible on discontinuation of treatment), hypotension, palpitation, peripheral oedema, cough, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, anaemia, angioedema, erythema.