REPAGLIN
REPAGLINIDE · by RAAZEE
Composition
Tab 0.5 mg/1 mg/2 mg: Repaglinide 0.5 mg/1 mg/2 mg.
Indications & Dosage
Type 2 diabetes mellitus monotherapy or in combination with metformin when metformin alone is unsatisfactory: Adult 18-74 years: Initially 500 mcg (max. per dose 4 mg) 30 minutes before main meals, adjusted according to response, at intervals of 1-2 weeks; max 16 mg per day; if transferring from another oral antidiabetic drug, initial dose 1 mg. Adult 75 yrs and above: Not recommended. Children: Not recommended.
Contraindications
Type I diabetes, ketoacidosis, severe renal or hepatic impairment, pregnancy and lactation.
Precautions
Debilitated patients and malnourished patients. Periodically monitor blood glucose and glycosylated haemoglobin.
Interactions
Azole anti fungals, erythromycin, mibefradil, rifampicin, phenytoin, MAOIs, beta-blockers, ACE inhibitors, salicylates, NSAIDs, octreotide, alcohol, anabolic steroids, oral contraceptives, thiazide diuretics, corticosteroids, danazol, thyroid hormones, sympathomimetics.
Pregnancy
Not recommended.
Lactation
Contraindicated or not recommended.
Side Effects
Abdominal pain, constipation, diarrhoea, nausea, vomiting, rash, transient elevation in liver enzymes. Rare: Hypersensitivity reactions, hypoglycaemia, pruritus, rashes, urticaria, vasculitis, visual disturbances.