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RETLI

RITLECITINIB · by HORIZON

ANTINEOPLASTICS Inhibitor of Janus-associated tyrosine kinase 3 (JAK3) HORIZON

Composition

Tab 50 mg: Ritlecitinib 50 mg

Indications & Dosage

Treatment of alopecia areata: Adults: 50 mg once daily with or without food at the same time everyday.

Contraindications

Hypersensitivity

Precautions

Serious infections, mortility, malignancy, risk of major adverse cardiovascular events (MACE) (discontinue), thrombosis.

Interactions

Carbamazepine, phenobarbital, phenytoin, rife-mycin, CYP3A4 inducers, Protease inhibitors, macrolides, azole antifungals and other CYP3A4 inhibitors, Fluconazole and other dual inhibitors of CYP3A4 or P-gp, Cytoreductive therapies, haematopoietic growth factors.

Pregnancy

Contraindicated in pregnancy.

Lactation

Contraindicated. Discontinue breast-feeding

Side Effects

Serious infection, malignancy mortility, malignancy and lymphoproliferative disorder, major adverse cardiovascular events (MACE), thrombosis thromboembolic event, hypersensitivity, laboratory abnormalities.