RONIM
DORIPENEM · by DANEEN
Composition
IV Inj: Doripenem 500 mg powder for injection
Indications & Dosage
Complicated Intra-abdominal Infection: BY IV INF: Adult: 500 mg IV INF over 1 hour every 8 hr for 5-14 days. Complicated UTI: BY IV INF: Adult: 500 mg IV INF over 1 hour every 8 hr for 10 days, can be extended up to 14 days if concurrent infection. Treatment of bronchopulmonary infection with cystic fibrosis: BY IV INF: Adult: 500 mg IV INF over 1 hour every 8 hr for max 14 days.
Administration
Reconstitute in 500 mg vial with 10 ml SWI or NS; shake gently to form suspension. Add to infusion bag containing 100 mL NS or D5W, shake gently until clear
Compatibility
Stable in SWFI, NS and D5W
Stability
Store dry powder at 20 C-25 C (68 F-77 F). Freshly prepared solutions should be used whenever possible. Reconstituted solutions are stable at 15 C-25 C (59 F-77 F), or under refrigeration at 4 C (39 F). Solutions should not be frozen.
Contraindications
Hypersensitivity to doripenem, beta-lactams or similar drugs
Precautions
History of sensitivity to multiple allergens, may reduce serum valproic acid concerntration to subtherapeutic level; monitor levels frequently, risk of Clostridium difficile-associated diarrhea on long-term use, seizures reported with use, not approved for ventilator-associated bacterial pneumonia (or any type of pneumonia); increased mortality
Interactions
Vaccine (BCG, Cholera,Typhoid), Probenecid, lactobacillus and estriol, sodium picosulphate and valproate products
Pregnancy
Caution advised, avoid
Lactation
Caution advised
Side Effects
Abdominal discomfort, diarrhoea, headache, nausea, pruritus, rash, anemia, phlebitis, transaminases elevated oral candidiasis. Rare: Anaphylaxis, leukopenia, neutropenia, seizure, thrombocytopenia, toxic epidermal necrolysis, Stevens-Johnson Syndrome, interstitial pneumonia, renal impairment/failure