Composition
Tab 0, 25 mg/1 mg/2 mg/5 mg: Ropinirole (as hydrochloride) 0.25 mg/1 mg/2 mg/5 mg.
Indications & Dosage
Parkinsons disease, either used alone or as adjunct to cobeneldopaor co-careldopa: Adult: Initially 0.75mg daily in 3 divided doses, then increased in steps of 0.75mg daily, dose to be increased at weekly intervals, increased to 3 mg daily in 3 divided doses, then increased in steps of1.5-3 mg daily, adjusted according to response, usual dose 9-16 mg daily in 3 divided doses, higher doses may be required if used with levodopa, when administered as adjunct to levodopa, concurrent dose of levodopa may be reduced by approx. 20%, daily max. dose to be given in3 divided doses; max. 24 mg per day. Moderate to severe idiopathic restless legs syndrome: Adult: Initially 0.25mg once daily for 2 days, increased if tolerated to 0.50 mg once daily for 5 days, then increased if tolerated to 1 mg once daily for 7 days, then increased in steps of 0.50 mg daily, adjusted according to response, dose to be increased at weekly intervals; usual dose 2 mg once daily, doses to be taken at night, repeat dose titration if restarting after interval of more than a few days; max. 4 mg per day.
Contraindications
Severe renal or severe hepatic impairment.
Precautions
Moderate hepatic impairment, elderly, major psychotic disorders, severe cardiovascular disease (risk of hypotension-monitor blood pressure). Withdraw gradually.
Interactions
Ciprofloxacin, enoxacin, fluvoxamine, HRT, starting or stopping smoking, neuroleptics, sulpiride, metoclo-pramide.
Pregnancy
Avoid unless potential benefit outweighs risk.
Lactation
Contraindicated
Side Effects
Gastro-oesophageal reflux disease, dizziness, drowsiness, abdominal pain, confusion, constipation, dyskinesia, dyspepsia, fatigue, hallucinations, hypotension, nausea, nervousness, peripheral oedema, sudden onset of sleep, syncope, vomiting, compulsive behavior, psychosis. Rare: Hepatic disorders