ROSCA-EZ
ROSUVASTATIN AND EZETIMIBE · by GENIX
Composition
Tab 5/10 mg: Rosuvastatin 5 mg and Ezetimibe10; Tab 10/10 mg: Rosuvastatin 10 mg and Ezetimibe10; Tab 20/10 mg: Rosuvastatin 20 mg and Ezetimibe10
Indications & Dosage
Hyperlipidemia: Adult: 5/10 mg to 20/10 mg daily Homozygous familial hypercholesterolemia: Adult: 5/10 mg to 20/10 mg daily
Contraindications
Active liver disease and decompensated cirrhosis
Precautions
Severe renal impairment (dosage adjustment required). Chronic alcoholic liver disease, elderly, uncontrolled hypothyroidism. Assess LDL-C when clinically appropriate 2 weeks after initiating therapy and adjusting dosage if necessary
Interactions
Atazanavir, ritonavir, saquinavir, clarithromycin, colchicine, cyclosporine, darolutamide, eltrombopag, fenofibrate, mifepristone, nelfinavir, niacin, Gemifibrzil (avoid).
Pregnancy
Contraindicated
Lactation
Contraindicated, avoid
Side Effects
Arthralgia, headache, dizziness, myalgia, nausea, abdominal pain, diarrhoea.