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SAMCOL

COLCHICINE · by SAMI

ANTI-GOUT PREPARATIONS Anti-gout/Plant Alkaloid SAMI

Composition

Tab: Colchicine 500 mcg (0.5 mg).

Indications & Dosage

Acute gout: Adult: 500 mcg 2-4 times a day until symptoms relieved, max. 6mg per course, do not repeat course within 3 days. Short-term prophylaxis during initial therapy with allopurinol and uricosuric drugs: Adult: 500 mcg twice daily. Prophylaxis of familial Mediterranean fever (recurrent polyserositis): Adult: 0.5-2 mg once daily. Children: Not recommended.

Contraindications

Blood disorder

Precautions

GI disease, cardiac disease, hepatic impairment, renal impairment, elderly

Interactions

Cyclosporin.

Pregnancy

Contraindicated in pregnancy

Lactation

Caution advised

Side Effects

Nausea, vomiting, and abdominal pain, excessive doses may also cause profuse diarrhoea, GI haemorrhage, rashes, renal and hepatic damage. Rare: peripheral neuritis, myopathy, alopecia, inhibition of spermatogenesis, and with prolonged treatment blood disorders.