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Composition

Tab 2.5 mg/5 mg: Saxagliptin 2.5 mg/5 mg.

Indications & Dosage

Type 2 diabetes mellitus as monotherapy or in combination with metformin or a sulfonylurea, or pioglitazone (duel therapy), and also in combination with both metformin and a sulfonylurea (triple therapy) to achieve adequate glycaemic control: Adults: 5 mg once daily. Type 2 diabetes mellitus in combination with insulin (with or without metformin) when insulin alone fails to provide adequate glycaemic control: Adults: 5 mg once daily. Dose of concomitant sulfonylurea or insulin may need to be reduced. Children: Below 18 yr, not recommended.

Contraindications

Diabetic ketoacidosis, renal impairment, Congestive heart failure, severe hepatic impairment.

Precautions

Immuno-compromised patients, elderly (above 75 years).

Interactions

potent CYP3A4/5 inducers.

Side Effects

Dizziness, dyspepsia, fatigue, gastritis, gastroenteritis, vomiting, headache, hypoglycaemia, myalgia, nasopharyngitis, peripheral oedema, sinusitis, respiratory and urinary tract infection, anaphylaxis, arthralgia, dyslipidaemia, erectile dysfunction, hypersensitivity reactions, hyper triglyceridaemia, pancreatitis (discontinue), rash.