SEBIVO
TELBIVUDINE · by NOVARTIS
Composition
Tab 600 mg: Telbivudine 600 mg. Soln 20 mg: Per ml: Telbivudine 20 mg.
Indications & Dosage
Treatment of chronic hepatitis B in patients with evidence of viral replication & active liver inflammation: Adults: 600 mg once daily. Renal impairment: CrCI30-49: 600 mg once every 48 hr; CrCI<30 (not requiring dialysis): 600 mg once every 72 hr; End stage renal disease: 600 mg once every 96 hr, administered after haemodialysis.
Contraindications
Hypersensitivity to telbivudine.
Precautions
Lactic acidosis, severe hepatomegaly with steatosis, myopathy, uncomplicated myalgia, renal impairment, patients with antiviral-resistant, HBV infection, liver transplant recipient, elderly.Monitor hepatic function in patients who have discontinued anti-hepatitis B therapy.
Interactions
Interferon alfa.
Pregnancy
Caution advised, avoid
Lactation
Caution advised, avoid
Side Effects
Dizziness, headache, increased blood amylase & lipase, diarrhoea, nausea; increased liver enzymes; increased blood creatine phosphokinase; rash, fatigue.