SOFOTEL
SOFOSBUVIR · by HELIX
Composition
Tab: Sofosbuvir 400 mg.
Indications & Dosage
In combination with ribavirin (with or without peginterferon alfa) for the treatment of chronic hepatitis C infection of genotypes 1, 3, 4, 5, or 6 in patients with compensated liver disease, OR in combination with ribavirin for chronic hepatitis C infection of genotype 2 in patients with compensated liver disease OR in combination with daclatasvir for chronic hepatitis C infection of genotype 1, 3, or 4: Adults: 400 mg once daily with food. Continue for up to 24 week.
Contraindications
Severe renal impairment.
Precautions
Decompensated cirrhosis, patients awaiting liver transplantation. Co-infection with HBV.
Interactions
Telaprevir, boceprevir, other direct-acting HCV antivirals. Modafinil, potent P-gp inducers (e.g. rifamycins, carbamazepine, phenytoin, phenobarbital)
Pregnancy
Avoid
Lactation
Avoid
Side Effects
Agitation, alopecia, anaemia, anxiety, arthralgia, asthenia, blurred vision, chest pain, constipation, decreased appetite, depression, diarrhoea, dizziness, dry mouth, dyspnea, gastro-oesophageal reflux, abdominal discomfort, headache, influenza-like symptoms, insomnia, irritability, memory impairment, migraine, myalgia, nausea, neutropenia,rash, vomiting, weight loss