Composition
Inj 250 mg/500 mg/1 gm/2 gm: Ceftizoxime (as sodium salt) 250 mg/500 mg/1 gm/2 gm; powder in vials.
Indications & Dosage
Infections of the lower respiratory tract, skin and soft tissues, Severe infections in immuno-compromised patients, UTI and gonorrhea: BY IM OR IV INJ: Adults: 1-2 gm every 8-12 hr, up to 2 gm every 4 hr or 4 gm every 8 hr for life-threatening infection; max 12 gm/day; Children 6 months: 50 mg/kg every 6-8 hr; not to exceed adult dose. Meningitis, Septicaemia: BY IV INJ: Adults: 3-4 gm every 8 hr. Children 6 months: 50 mg/kg every 6-8 hr, not to exceed adult dose.
Administration
Inject deep IM into large muscle mass. Inject direct IV over 3-5 min. Infuse intermittent infusion over 30 min. Reconstitute for IV with SWFI as follows: For 500 mg vial: Add 5 ml, 1 gm vial: Add 10 ml, 2 gm vial: Add 20 ml. Shake well. Dilute reconstituted solution further with 50-100 ml of a compatible solution, such as NS or D5W before administration. Reconstitute for IM with SWFI as follows: For 500 mg vial: Add 1.5 ml, 1 gm vial: Add 3 ml. 2 gm vial: Add 6 ml. Shake well. Divide 2 gm doses and ad-minister in different sites.
Compatibility
Stable in D5/NS, DT/AS, D5NS, D5W, 010W, LR, NS, sodium bicarbonate 5%.
Precautions
Hepatic and renal impairment, hypersensitivity
Interactions
Aminoglycosides, loop diuretics
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, hallucinations, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis