Composition
Tab 25 mcg/50 mcg/75 mcg/88 mcg/100 mcg/112 mcg/125 mcg/137 mcg/150 mcg/175 mcg/200 mcg/300 mcg: Levothyroxine 25 mcg/50 mcg/75 mcg/88 mcg/100 mcg/112 mcg/125 mcg/137 mcg/150 mcg/175 mcg/200
Indications & Dosage
Hyperthyroidism: Adult: 15-40 mg daily continue until the patient becomes euthyroid, usually after 4 to 8 weeks, higher doses should be prescribed under specialist supervision only, then reduced to 5-15 mg daily, reduce dose gradually, therapy usually given for 12 to 18 months Children: Initially, 5-15 mg daily in divided doses. Thyrotoxicosis: Adults: Initially, 20-60 mg daily in two or three divid-ed doses until patient is euthyroid. Maintenance; 5-15 mg daily for 6-18 months, Alternatively, continue with 20-60 mg daily and supplemental thyroxine 50-150 mcg daily for 6-18 months. Children: Initially, 5-15 mg daily in divided doses.
Contraindications
Thyrotoxicosis
Precautions
Cardiovascular disorders, diabetes insipidus, diabetes mellitus, elderly, hypertension, long-standing hypothyroidism, myocardial infarction, myocardial insufficiency, panhypopituitarism and predisposition to adrenal insufficiency (initiate corticosteroid therapy before starting levothyroxine)
Interactions
Anticoagulants, cholestyrarnine, pherrytoin, digi-talis, insulin, antidiabetic therapy.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Anginal pain, arrhythmias, diarrhoea, excitability, fever, flushing, headache, heat, intolerance, hypersensitivity reactions, insomnia, muscle cramp, muscular weakness, oedema, palpitation, pruritus, rash, restlessness, sweating, tachycardia, transient hair loss in children, tremor