TADALIS
TADALAFIL · by HILTON
Composition
Tab 2.5/5/10/20 mg: Tadalafil 2.5/5/10/20 mg
Indications & Dosage
Pulmonary Arterial Hypertension (initiated under specialist supervision): Adult: 40 mg once daily Erectile dysfunction Adult: Initially 10 mg (max. per dose 20 mg), to be taken at least 30 minutes before sexual activity, subsequent doses adjusted according to response, the effect of intermittent dosing may persist for longer than 24 hours, maximum 1 dose per day. Erectile dysfunction; for patients who anticipate sexual activity at least twice a week: Adult: 5 mg once daily, reduced to 2.5 mg once daily, adjusted according to response Benign prostatic hyperplasia: Adult: 5 mg once daily
Contraindications
Acute myocardial infarction in past 90 days, history of non-arteritic anterior ischaemic optic neuropathy, hypotension (systolic blood pressure below 90 mmHg), mild to severe heart failure, patients in whom vasodilation or sexual activity are inadvisable, recent stroke, uncontrolled arrhythmias, uncontrolled hypertension, unstable angina.
Precautions
Anatomical deformation of the penis (e.g. angulation, cavernosal brosis, Peyronie’s disease), cardiovascular disease, left ventricular outflow obstruction, predisposition to priapism (e.g. in sickle-cell disease, multiple myeloma, or leukaemia), aortic and mitral valve disease, congestive cardiomyopathy, coronary artery disease, hereditary degenerative retinal disorders. left ventricular dysfunction, life-threatening arrhythmias, pericardial constriction, pulmonary veno-occlusive disease, uncontrolled hypertension, Elderly.
Interactions
Phosphodiesterase type-5 inhibitors
Pregnancy
Use only if potential bene t outweighs risk, avoid
Lactation
Avoid
Side Effects
Headaches, flushing, GI discomfort, myalgia, nasal congestion, pain, arrhythmias, chest pain, dizziness, dyspnoea, eye pain, fatigue, gastrooesophageal reflux disease, haemorrhage, hypertension, hypotension, nausea, oedema, palpitations, skin reactions, tinnitus, vision disorders, vomiting. Rare: Acute coronary syndrome, angioedema, cerebrovascular insufficiency, eye erythema, eye swelling, haematospermia, hyperhidrosis, memory loss, optic neuropathy (discontinue), priapism, retinal occlusion, seizure, Stevens- Johnson syndrome, sudden cardiac death, sudden hearing loss (discontinue), syncope.