TAGAMICRON
GLICLAZIDE · by TAGMA
Composition
Tab 60 mg/80 mg: Gliclazide 60 mg/80 mg. Tab MR 30 mg: Gliclazide 30 mg.
Indications & Dosage
Type 2 diabetes: Adults: Adult: Initially 30 mg daily with breakfast, adjust dose according to response every 4 wks (after 2 wks if no decrease in blood glucose); max 120 mg per day. Maturity-onset diabetes: Adults: Initially 40-80 mg daily with breakfast, adjusted according to response, increased if necessary up to 160 mg once daily, doses higher than 160mg to be given in divided doses; max 320 mg per day. Children: Not recommended.
Contraindications
Acute porphyrias, insulin-dependent diabetes, diabetic ketoacidosis, pre-coma and coma, severe renal or hepaticin sufficiency.
Precautions
Children, avoid if the patient has both renal and hepatic impairment.
Interactions
Miconazole, phenylbutazone, alcohol, insulin, acarbose, biguanides, beta-blockers, fluconazole, ACE in hibitors, H2 receptor antagonists, MAOls. sulphonamides, NSAIDs, danazol, chlorpromazine, glucocorticoids, ritodrine, salbutamol, terbutaline, anticoagulants.
Pregnancy
Contraindicated in pregnancy.
Lactation
Caution advised, avoid.
Side Effects
Hypoglycaemia, dermatological reactions, GI disturbances, brain damage, dizziness.