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TAPTAN PLUS

TELMISARTAN AND HYDROCHIOROTHIAZIDE · by ACE LIFE SCIENCES

ANGIOTENSIN-II ANTAGONISTS, COMBINATIONS Angiotensin II antagonistrfhiazide diuretic ACE LIFE SCIENCES

Composition

Tab 20/12.5 mg: Telmisartan 20 mg, hydrochlorothiazide 12.5 mg.Tab40/12.5 mg: Telmisartan 40 mg, hydrochlorothiazide 12.5 mg. Tab80/12.5 mg:Telmisartan 80 mg, hydrochlorothiazide 12.5 mg.

Indications & Dosage

Hypertension not adequately controlled by telmisartan alone: Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.

Contraindications

Cholestasis, biliary obstruction, severe hepatic or severe renal impairment, refractory hypokalaemia; hypercalcaemia.

Precautions

Mild to moderate renal or hepatic impairment, progressive liver disease, renovascular hypertension, kidney transplant, intravascular vol-ume depletion, severe congestive heart failure, renal artery stenosis, primary aldosteronism, aortic or mitral stenosis, obstructive cardiomyopathy, diabetes. Monitor serum electrolyte, creatinine and uric acid levels during therapy.

Interactions

Lithium, digoxin, diuretics, corticosteroids, ACE inhibitors, K+-sparing diuretics or K+ supplements, cyclosporin, tacrolimus, hypoglycaemic agents, anionic exchange resins, NSAIDS, pressor amines, allopurinol, probenecid, sulfnpyrazone, calcium supplements, diazoxide, beta-blockers, anticholinergics, amantadine, methotrexate, cyclophosphamide, baclofen, alcohol barbiturates, antidepressants.

Pregnancy

Contraindicated in pregnancy.

Lactation

Not recommended.

Side Effects

Arthralgia, back pain, chest pain, eczema, GI disturbances, influenza-like symptoms, leg cramps, myalgia, pharyngitis, sinusitis, urinary-tract infection, asthenia, syncope, abnormal vision, anxiety, dry mouth, flatulence, sweating, tendinitis-like symptoms, vertigo. Rare: Blood disorders, bradycardia, depression, dyspnea, eosinophilia, increase in uric acid, insomnia, pruritus, rash, tachycardia