Composition
Tab2/180 mg: Trandolapril 2 mg, verapamil hydro-chloride 180 mg. Tab 1/240 mg: Trandolapril 1 mg, verapamil hydrochloride 240 mg. Tab 2/240 mg: Trandolapril 2 mg, verapamil hydrochloride 240
Indications & Dosage
Hypertension not adequately controlled by mono-therapy: Adults: 1 tab daily in the morning. If on diuretics, discontinue first and initiate therapy under close supervision. Children: Not applicable.
Contraindications
History of angioneurotic oedema; hereditary, idiopathic, or due to previous ACE inhibitor therapy, cardiogenic shock, recent MI with complications, 2nd or 3rd degree AV block without pacemaker, SA block, sick sinus syndrome, severe bradycardia, congestive heart failure, severe renal impairment, dialysis, liver cirrhosis with ascites, aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy, primary aldosteronism.
Precautions
Salt or volume depletion. Moderate renal impairment monitor renal function, bilateral renal artery stenosis, hepatic impairment, conduction disturbances, bradycardia, surgery, elderly.
Interactions
Potassium sparing diuretics, Potassium supple-ments, dantrolene, lithium, anaesthetics, CNS depressants, allopurinol, cytostatics, immunosuppressants, corticosteroids, procainamide, cardiodepressants, quinidine, digoxin, muscle relaxants, NSAIDs, antacids, sympathomimetics, carbamazepine, cyclosporin, theophylline, rifampicin, phenytoin, barbiturates, cimetidine, antidiabetic agents, grapefruit juice.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Alopecia, angina, arrhythmias, asthenia, bronchitis, cerebral haemorrhage, dry mouth, dyspnea, hot flushes, ileus, myocardial infarction, nervousness, palpitation, psoriasis-like efflorescence, skin reactions, sleep disturbances, Stevens-Johnson syndrome, sweating, syncope, tachycardia, toxic epidermal necrolysis, transient ischaemic attacks