Composition
Tab 400 mg: Telithromycin 400 mg. Pregnancy: Risk cannot be ruled out.
Indications & Dosage
Mild or moderate community acquired pneumonia, acute exacerbation of chronic bronchitis, acute sinusitis. Tonsillitis or pharyngitis caused by Group A beta streptococci when beta lactam antibiotics are inappropriate: Adults: 800 mg once daily for 5 days. Pneumonia: Adult: 800 mg once daily for 7-10 days.
Contraindications
History of QT prolongation, pseudomembranous colitis.
Precautions
Hepatic or severe renal impairment, coronary heart disease, ventricular arrhythmia, hypokalaemia, hy-pomagnesaemia andbradycardia. Stop treatment if any signs of hepatic disease develop.
Interactions
Cisapride, ergot derivatives, pimozide, astemizole, terfenadine, simvastatin, atorvastatin, lovastatin, QT prolonging agents, CYP3A4 inhibitors, inducers or substrates, CYP2D6 substrates, digoxin, theophylline, warfarin.
Pregnancy
Risk cannot be ruled out.
Lactation
Caution advised or effect undetermined.
Side Effects
Abdominal discomfort, diarrhoea, nausea, vomiting, cholestatic jaundice, hepatotoxicity, rash, anorexia, arthralgia, disturbances in taste and vision, dizziness, dyspepsia, flatulence, headache, malaise, paraesthesia, anxiety, chest pain, constipation, gastritis, hypoaesthesia, leucopenia, oedema, photosensitivity, sleep disturbances, acute renal failure, convulsions, haemolytic anaemia, interstitial nephritis, syncope, thrombocytopenia, tongue discoloration. Rare: Agitation, antibiotic-associated colitis, arrhythmias, pancreatitis, QT interval prolongation, Stevens-Johnson syndrome, toxic epidermal necrolysis. With intravenous use; Local tenderness and phlebitis