Composition
Inj: Testosterone oenanthate 250 mg in oily soln, amp. Gei: Testosterone 50 mg
Indications & Dosage
Hypogonadism in men: BY SLOW IM INJ: Adult: 250 mg IM every 2-3 weeks. To maintain an adequate androgenic effect 250 mg IM every 3-6 weeks. Potency disorders: BY SLOW IM INJ: Adult: 100 mg IM once a week, Continue treatment with 100 mg IM, then 50 mg IM every 2-4 week. Male climacteric: BY SLOW IM INJ: Adult: 50-100 mg IM every 2-3 weeks. Repeat 6-8 weeks courses at 4 weeks intervals are recommended. Male infertility: BY SLOW IM INJ: Adult: 50 mg IM every 2 wk for 90 days. Progressive mammary or endometrial carcinoma, climacteric complaints with existing mammary or endometrial carcinoma in female: BY SLOW IM INJ: Adult: 250 mg every 2-3 weeks. Primary Hypogonadism (congenital or acquired), Hypogonadotropic hypogonadism (congenital or acquired): By Topical Application: Adult: 5 gm gel applied topically once daily, increase to 7.5 mg to 10 mg once daily if serum testosterone level is below normal range.
Administration
Warm injection to room temperature and shaking vial will help dissolve crystals that have formed after storage. Administer by deep IM injection into the upper outer quadrant of the gluteus maximus.
Stability
Store at room temperature
Contraindications
Carcinoma of the male breast or prostate, hypercalcaemia, impaired liver function, pregnancy, lactation.
Precautions
Cardiac, hepatic or renal insufficiency, epilepsy, migraine, hypertension. Large and repeated doses in puberty may cause premature epiphyseal closure and stop linear growth. Hepatic adenocarcinoma may develop with prolonged use. In women high doses long term therapy produces virilism including irreversible voice deepening.
Interactions
In diabetic patients' the metabolic effect of androgen may decrease blood glucose and insulin or hypo-glycaemic agent requirements,
Side Effects
Female: Amenorrhoea and other menstrual irregularities. Male: Gynaecomastia, excessive frequency and duration of penile erections, inhibition of testicular function, testicular atrophy, impotence, Suppression of spermatogenesis