Composition
Cap/Tab 250 mg: Oxytetracycline 250 mg. IM Inj 100 mg: Per 2 ml amp: Oxytetracycline 100 mg. IV Inj 250 mg: Per 3 ml amp: Oxytetracycline 250 mg.
Indications & Dosage
Susceptible infections including chlamydia, rickettsia, mycoplasma and other oxytetracycline sensitive infections: ORAL: Adults: 250-500 mg every 6 hr. Children:25-50 mg/kg every 6 hr. BY IM INJ: Adults: 250 mg every 6 hr or 300 mg every 8 hr or every 12 hr. Children: 15-25 mg/kg body-wt up to max 250 mg daily inj. The dosage may be divided at 8 or 12 hourly intervals.
Administration
For an adult, give IM inj in upper outer quadrant of buttocks or mid-lateral thigh. Deltoid muscle may be used but only if well developed. In children, give injection only in mid-lateral thigh.
Contraindications
Renal impairment, avoid use in children less than 8 years, unless no alternative (deposition in growing bone and teeth, by binding to calcium, causes staining and occasionally dental hypoplasia)
Precautions
Hepatic impairment, SLE, myasthenia gravis (muscle weakness may be increased), systemic lupus erythematosus (may be exacerbated), avoid exposure to sunlight or UV light, risk of super-infection.
Interactions
Milk, antacids, mineral supplements, oral contraceptives.
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated, avoid
Side Effects
Anaphylaxis, angioedema, blood disorders, exfoliative dermatitis, hepatotoxicity, hypersensitivity reactions, pancreatitis, pericarditis, photosensitivity, rash, Stevens-Johnson Syndrome, urticaria, colitis, benign intracranial hypertension, bulging fontanelles, diarrhoea, dysphagia, headache, nausea, oesophageal irritation, visual disturbances, vomiting, enamel hypoplasia,reduced fibula growth rate,GIdisturbance, allergic reactions, superinfections.