Composition
Cap 5 mg: Tropisetron (as HCI) 5 mg. Inj 2 mg: Per 1 ml: Tropisetron (HCI) 1 mg; 2 ml (2 mg) amp. Inj 5 mg: Per 1 ml: Tropisetron( HCI) 1 mg; 5 ml (5 mg) amp.
Indications & Dosage
Nausea and vomiting induced by chemotherapy: BY SLOW IV INJ OR INF: Adults: 5 mg by slow IV inj or INF shortly before chemotherapy followed by 1 cap each morning 1 hr before food for 5 days. Children above 2 yr: 0.2 mg/kg by slow IV inj or INF shortly before chemotherapy up to a max daily dose of 5 mg. In children under 25 kg, repeat IV administration on day 2 up to day 5 depending on chemotherapy regimen, in children over 25 kg, 5 mg orally on day 2 up to day 6. Prevention of post-operative nausea and vomiting: BY SLOW IV INJ OR INF: Adults: 2 mg dose by slow IV or INF shortly before induction of an-aesthesia. Treatment of post-operative nausea and vomiting: BY SLOW IV INJ OR INF: Adults: One 2 mg dose by IV or INF within 2 hr of the end of an-aesthesia.
Administration
Intermittent or via drip tubing in dextrose 5% or NaCI 0.9% or Ringers solution. Suggested concentrationfor infusion is 50 meg/ ml.
Precautions
Liver impairment, hypertension, cardiac rhythmor conduction disturbances.
Interactions
Rifampicin and drugs affecting liver enzymes or prolong QT interval.
Pregnancy
Contraindicated
Lactation
Caution advised
Side Effects
Fatigue, dizziness, headache, constipation, GI disturbance, rarely collapse, syncope, bradycardia, cardiovascular arrest.