Composition
Tab 5 mg/10 mg: Metolazone 5 mg/10 mg
Indications & Dosage
Oedema: Adult: 5–10 mg daily, dose to be taken in the morning; increased if necessary to 20 mg daily; max. 80 mg per day Hypertension: Adult: Initially 5 mg daily, dose to be taken in the morning; maintenance 5 mg once daily on alternate days.
Contraindications
Addison’sdisease, hypercalcaemia, hyponatraemia, refractory hypokalaemia, symptomatic hyperuricaemia.
Precautions
Diabetes, gout, acute porphyrias, systemic lupus erythematosus, hyper-aldosteronism, malnourishment, nephrotic syndrome, avoid in severe renal disease, patients with moderate to high cholesterol concentrations.
Interactions
Beta-blockers, ACE inhibitors, neuromuscular blocking agents, oral hypoglycaemics, NSAIDs.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Appetite decreased, arthralgia, asthenia, chest discomfort, chills, drowsiness, GI discomfort, glycosuria, gout aggravated, haemoconcentration, hepatic disorders, hypoplastic anaemia, hypovolaemia, palpitations, peripheral neuropathy, psychotic depression, severe cutaneous adverse reactions (SCARs), syncope, vasculitis, venous thrombosis, vertigo, vision blurred