Composition
Inj 10 mg: Vinblastine sulphate 10 mg; vial.
Indications & Dosage
Hodgkins disease, Lymphocytic lymphoma, Histiocytic lymphoma, Advanced mycosis fungoides, Advanced testicular cancer, Kaposis sarcoma, LettererSiwe disease, Resistant choriocarcinoma, Unresponsive breast cancer: BY IV INJ OR INF: Adults: At weekly intervals:1st dose=3.7 mg/m2, 2nd dose=5.5 mg/m2, 3rd dose=7.4 mg/m2, 4th dose=9.25 mg/m2, 5th dose= 11.1 mg/m2, increase to a max 18.5 mg/m2. Children: At weekly intervals: 1st dose=2.5 mg/ rn2, 2nd dose=3.75 mg/m2, 3rd dose=5 mg/m2, 4th dose=6.25 mg/m2, 5th dose= 7.5 mg/m2, increase to a max 12.5 mg/m2.
Administration
For IV administration only, usually as a slow (2-3 min) push, or a bolus (5-15 min) infusion. It is occasionally given as a 24-hour continuous infusion. Reconstitute to a cone of 1 mg/ml with bacteriostatic water, bacteriostatic NS, SWFI, NS, or D5W; for infusion, may be diluted with 50-1000 ml NS or D5W.
Compatibility
Stable in D5W, LR, NS, bacteriostatic water.
Contraindications
Bone marrow suppression.
Precautions
Intrathecal administration can cause severe neurotoxicity which may result in death.
Interactions
Mitomycin C, CYP3A4 enzyme inhibitors.
Pregnancy
Positive evidence of risk: Avoid
Lactation
Contraindicated. Discontinue breast-feeding
Side Effects
Alopecia, autonomic neuropathy, hyperuricaemia, loss of deep tendon reflexes, motor weakness, myelosuppression(dose-limiting), nausea neurotoxicity, oral mucositis, ototoxicity, peripheral neuropathy, peripheral paraesthesia, severe bronchospasm following administration, severe local irritation, thromboembolism, tumourlysis syndrome, vomiting