Composition
Cap 10 mg: tretinoin 10 mg
Indications & Dosage
Induction of remission in acute promyelocytic leukaemia (untreated patients, relapsed or refractory): Adult: 45 mg/m2 daily in 2 divided doses max. duration of treatment is 90 days, consult product literature for details of concomitant chemotherapy.
Precautions
Renal or hepatic impairment. Monitor haematology, coagulation, liver function and serum lipids frequently. Increased risk of thromboembolism during first month of treatment
Interactions
progestone-only contraceptives, tetracyclines, Vit A, liver enzyme inducers and inhibitors
Pregnancy
Contraindicated.
Lactation
Contraindicated. Discontinue breast-feeding
Side Effects
Alopecia, anxiety, arrhythmias, benign intracranial hypertension, bone pain, cheilitis, confusion, depression, dizziness, erythema, flushing, GI disturbances, genital ulceration, hearing disturbances, hypercalcaemia, insomnia, oedema, pancreatitis, paraesthesia, pruritus, raised lipids, raised liver enzymes, raised serum creatinine, rash, retinoic acidsyndrome, shivering, thromboembolism, visual disturbances