VETO-S
MYCOPHENOLATE SODIUM · by SCHAZOO PHARMA
Composition
Tab DR: 180 mg/360 mg: Mycopheholate Sodium 180 mg/360 mg.
Indications & Dosage
Prophylaxis of organ rejection in patients receiving alogenic renal transplantation (in combination with a corticosteroid and cyclosporin): Adult: 720 mg twice daily (1440 mg total daily dose) to be taken on an empty stomach, to be started within 72 hours of transplantation.
Contraindications
Pregnancy, lactation.
Precautions
Monitor full blood count every week for 4 weeks then twice a month for 2 months then every month in the first year (consider interrupting treatment if neutropenia develops). Active serious GI disease (risk of haemorrhage, ulceration and perforation), delayed graft, function, elderly, increased susceptibility to skin cancer (avoid exposure to strong sunlight), risk of hypogamma globulinaemia or bronchiectasis when used in combination with other immunosuppressants. Measure serum immunoglobulin levels if recurrent infections develop, and consider bronchiectasis or pulmonary fibrosis if persistent respiratory symptoms such as cough and dyspnea develop.
Interactions
Acyclovir, valaciclovir, ganciclovir, antacids, azathioprine, cholestyramine, probenecid, vaccines, tacrolimus
Side Effects
Abdominal pain, acne, agitation, alopecia, anaemia, anorexia, anxiety, arthralgia, blood disorders, confusion, constipation, convulsions, cough, depression, disturbances of electrolytes and blood lipids, dizziness, dyspnea, GI upset, GI bleeding, GI inflammation, GI ulceration, gingival hyperplasia, hepatitis, hyperglycaemia, hypertension, hypotension, infections, influenza-like syndrome, insomnia, jaundice, leucopenia, malignancy, myasthenic syndrome, oedema, pancreatitis, pancytopenia, paraesthesia, rash, red cell aplasia, renal impairment, skin hypertrophy, stomatitis, tachycardia, thrombocytopenia, tremor, vasodilatation, weight loss, interstitial lung disease, intestinal villous atrophy, progressive multifocal leucoencephalopathy, pulmonary fibrosis