Composition
Tab 50 mg/100 mg: Fluvoxamine maleate 50 mg/100 mg.
Indications & Dosage
Depressive illness: Adult: Initially 50-100 mg daily in the evening, increased gradually if necessary up to 300 mg daily, doses over 150mg daily are given in divided doses; maintenance 100 mg daily. Children: 8-17 yrs: Initially 25 mg every night, increase by 25 mg every 4-7 day. Maintenance: 50-200 mg/day; max 200 mg/day. Obsessive-compulsive disorder: Adult: Initially 50 mg daily in the evening, increased gradually if necessary after several weeks, up to 300 mg daily; maintenance 100-300 mg daily, doses over 150mg daily are given in divided doses, if no improvement in obsessive-compulsive disorder within 10 weeks, treatment should be reconsidered. Children: 8-17 yr: Initially 25 mg every night, increase by 25 mg after week. Maintenance: 50-200 mg/day; max 200 mg/day.
Contraindications
History of epilepsy.
Precautions
Hepatic or renal insufficiency.
Interactions
Propranolol, theophylline, phenytoin, warfarin, MAOls, alcohol, lithium, tryptophan.
Pregnancy
Avoid unless potential benefit outweighs risk
Lactation
Contraindicated, avoid
Side Effects
Ataxia, malaise, palpitation, tachycardia, confusion, postural hypotension, neuroleptic malignant syndrome-like event, paraesthesia, taste disturbance, nausea and vomiting, somnolence, diarrhoea, agitation, anorexia, tremor, convulsions. Rare: Abnormal liver function, usually symptomatic