WARDIN
WARFARIN · by PHARMEDIC
Composition
Tab: Warfarin sodium 1 mg/2 mg/2.5 mg/3 mg/ 5 mg/7.5 mg/10 mg.
Indications & Dosage
Prophylaxis of embolisation in; rheumatic heart disease, atrial fibrillation, and after insertion of prosthetic heart valve, Prophylaxis and treatment ofvenous thrombosis and pulmonary embolism, Transient ischaemic attacks: Adult: Initially 5-10 mg, on day 1; subsequent doses dependent on the prothrombin time, reported as INR (international normalised ratio), a lower induction dose can be given over 3-4 weeks in patients who do not require rapid anticoagulation. Elderly: a lower induction dose; maintenance 3-9 mg daily, Children: Not recommended.
Contraindications
Haemorrhagic conditions, impaired renal or hepatic function, should not be used within 24 hours of surgery or labour.
Precautions
Hypertension. Weight changes, elderly, renal impairment, acute illness, vit K deficiency
Interactions
NSAlDs, oral hypoglycemics, sulphonamides, quinidine, antibiotics, phenformin, cimetidine, drugs affecting liver enzymes, corticosteroids, imidazole antifungals, tarnoxifen.
Pregnancy
Contraindicated
Lactation
Caution advised
Side Effects
Alopecia, rash, diarrhoea, fall in haematocrit. Rare: warfarin use may lead to Calciphylax is, patients should consult their doctor if they develop a painful skin rash; if Calciphylaxis is diagnosed, stop treatment.