ZINAMID
PYRAZINAMIDE · by WILSHIRE
Composition
Tab: Pyrazinamide 500 mg. Syp: Per 5 ml: Pyrazinamide 250 mg.
Indications & Dosage
Tuberculosis, in combination with other drugs (standard unsupervised 6-month treatment): Adult: 1.5-2 g once daily for2 months (initial phase). Children: 35 mg/kg once daily for 2 months (initial phase); max. 1.5 g per day. Tuberculosis, in combination with other drugs (intermittent supervised 6-month treatment): Adult: 2-2.5 g 3 times a week for 2 months (initial phase). Children: 50 mg/kg 3 times a week (max. per dose 2 g 3 times a week) for 2 months (initial phase).
Contraindications
Liver disease.
Precautions
History of gout or diabetes, perform frequently liver function tests and blood uric acid determinations; withdraw treatment if liver damage or hyperuricaemia accompanied by acute gouty arthritis occurs. Renal and hepatic function should be checked before treatment
Interactions
Probenecid, sulfinpyrazone, oral typhoid vaccine.
Pregnancy
Caution advised, use only if potential benefit outweighs risk
Lactation
Caution advised
Side Effects
Anorexia, arthralgia, dysuria, fever, flushing (in adults), hepatomegaly, hepatotoxicity, jaundice, liver failure, nausea, photosensitivity, rash, sideroblastic anaemia, splenomegaly, thrombocytopenia, vomiting