ZIPROWIN
ZIPRASIDONE · by WNSFEILD
Composition
Cap/Tab 20 mg/40 mg/60 mg/80 mg: Ziprasidone 20 mg/40 mg/60 mg/80 mg.
Indications & Dosage
Schizophrenia and other psychoses: Adult: Initially 20 mg twice daily, max: 80 mg twice daily. Bipolar disorder, Acute manic and mixed episodes: Adult: Initially40 mg twice daily, increase to 60-80 mg twice daily on 2nd day of treatment; maintenance: 40-80 mg twice daily.
Contraindications
QT-interval prolongation, recent myocardial infarction, uncompensated heart failure, cardiac arrhythmias, drugs that prolong QT interval.
Precautions
Neuroleptic malignant syndrome, tardive dyskinesia, hyperglycaemia, seizures, CNS drugs/alcohol.
Interactions
Class IA & Ill antiarrhythmics, drugs that prolong QT interval, CNS drugs/alcohol.
Pregnancy
Avoid unless potential benefit outweighs risk
Lactation
Contraindicated, avoid
Side Effects
Acute dystonic reactions such as facial and skeletal muscle spasms and oculogyric crises, leucopenia, hyperprolactinaemia, acute dyskinesias, akathisia, Parkinsonism, drowsiness, insomnia, agitation, tachycardia, arrhythmias; ECG changes, hypotension, antieholinergiceffects (e.g. dry mouth, blurred vision), respiratory depression, rash, photosensitivity, hypoglycaemia, impaired tem-perature regulation, convulsions, male sexual dysfunction, rarely, agranulocytosis, tardive dyskinesia, jaundice, neuroleptic malignant syndrome, pigmentary retinopathy