BIOTIC-P
BENZATHINE PENICILLIN G · by ENGLISH PHARMA
Composition
Inj 0.6 MIU: Benzathine penicillin G 0.6 MIU (long acting), vial. Inj 1.2 MIU: Benzathine penicillin G 1.2 MIU (long acting), vial.Inj 2 Benzathine penicillin G 2.4 MIU (long acting), vial
Indications & Dosage
Mild to severe streptococcal infections Group A of upper respiratory tract, skin and soft tissues, scarlet fever, erysipelas, otitis media: BY DEEP IM INJ: Adults: 2.4 million units. Children: 30-60 lbs, 0.9-1.2 million units; infants & children under 30 lbs., 0.6 million units, injection at a single session using multiple IM sites when indicated. Alternatively, give 1/2 the total dose on day 1 and remaining 1/2 of total dose on day 3. Pneumococcal infections (except pneumococcal meningitis): BY DEEP IM INJ: Adults: 1.2 million units. Children: 0.6 million units, repeated every 2 or 3 days until the temperature is normal for 48 hr.
Administration
Give undiluted injection; administer by deep IM injection in the upper outer quadrant of the buttock; do not give IV, intra-arterially or SC. IM injections should be made into the mid lateral muscle of the thigh.
Stability
Store in refrigerator.
Contraindications
History of previous hypersensitivity reaction to penicillins and/or cephalosporins.
Precautions
Avoid small ineffective doses of penicillin as resistant organisms are more likely to emerge, therapy must be sufficient to eliminate the streptococcal organism (a minimum of ten days), otherwise the sequela of streptococcal disease (endocarditis, rheumatic fever) may occur. Serious fatal immediate hypersensitivity (anaphylactoid) reactions have been reported. Do not inject parenteral solutions into or near an artery or nerve
Interactions
Concurrent administration of bacteriostatic anti-biotics (e g. erythromycin, tetracycline) may diminish the bactericidal effects of penicillins. Probenecid prolongs penicillkl blood levels. Oral contraceptives may be rendered less effective & an increased incidence of breakthrough bleeding may occur when administered with ampicillin or penicillin V
Pregnancy
No evidence of harm
Lactation
Caution advised
Side Effects
GI disturbances, anaemias, anaphylaxis, glossitis, stomatitis, gastritis, sore throat, dry mouth, furry tongue, Hemorrhagic manifestation, interstitial nephritis (e.g oliguria, hematuria), nephrotoxicity, accumulation of sodium from injection can occur in renal failure. High doses may cause neurotoxicity, including cerebral irritation, convulsions, or coma.