Composition
Tab 50 mg/100 mg: Trazodone 50 mg/100 mg. Drop: Per 5 ml: Trazodone 50 mg.
Indications & Dosage
Depressive illness (particularly where sedation is required): Adult: Initially 150 mg daily in divided doses, dose to be taken after food, alternatively initially 150 mg once daily at bedtime, increased if necessary to 300 mg daily; increased if necessary to 600 mg daily in divided doses, higher dose for use in hospital patients only. Elderly: Start with reduced dose then increase. Anxiety: Adult: 75 mg daily, increased if necessary to 300 mg daily.
Contraindications
Acute porphyrias, arrhythmias, during the manic phase of bipolar disorder, heart block, immediate recovery period after myocardial infarction
Precautions
Cardiovascular disease, diabetes, epilepsy, history of bipolar disorder, history of psychosis, hyperthyroidism, chronic constipation, increased intra-ocular pressure, patients with risk of suicide, phaeochromocytoma, prostatic hypertrophy, susceptibility to angle-closure glaucoma, urinary retention, severe hepatic, renal disease. Monitor for suicidal ideation.
Interactions
Potent CYP3A4 inhibitors, carbamazepine, muscle relaxants, volatile anaesthetics, alcohol, CNS depressants, MAOls, clonidine, digoxin, phenytoin.
Side Effects
Abdominal pain, agitation, alopecia, anorexia, anxiety, arrhythmia, blurred vision, fatigue, hypertension, mydriasis, restlessness, confusion, convulsions, delusions, dizziness, drowsiness, dry mouth, dysarthria, ECG changes, flushing, galactorrhoea, gynaecomastia, haematological reactions, hallucinations, heart block, hepatic reactions, hypomania, hyponatraemia, irritability, mania, oedema, paraesthesia, photosensitivity, postural hypotension, pruritus, rash, sexual dysfunction, sleep disturbances, stomatitis, sudden death of patients with cardiac disease, suicidal behavior, sweating, tachycardia, taste disturbance, tinnitus, tremor, urinary retention, urticaria, vomiting, weight changes. Rare: Extrapyramidal symptoms, paralytic ileus